Mitochondrial dynamics in neurodegeneration
نویسندگان
چکیده
منابع مشابه
Mitochondrial dynamics in neurodegeneration: from cell death to energetic states
From Parkinson’s disease to an ischemic stroke, a consistently reoccurring theme in the context of neuronal degeneration is the dysfunction of mitochondria as the underlying factor. Insight into the mechanistic basis for mitochondrial dysfunction in neurodegenerative disorders has allowed the theme of mitochondrial dynamics to be highlighted as a central player. The precise balance of mitochond...
متن کاملMitochondrial Dysfunction in Neurodegeneration
The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). One example of this is mitochondria...
متن کاملImplications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission. The importance of these events in cell physiology and pathology has been partially unraveled with the identification of the genes responsible for the catalysis of mitochondrial fusion and fission. Muta...
متن کاملTopic: Mitochondrial Dysfunction in Neurodegeneration
Neurodegenerative diseases such as Parkinson's disease (PD) are of growing public health concern in developed countries and the need for novel effective treatments continues to increase. Neurodegenerative diseases take many forms, reflecting the degeneration of different populations of neurons at different times from distinct causes, but many of them also share common features. Amongst the comm...
متن کاملNeurodegeneration in Primary Mitochondrial Disorders
A.K. Reeve et al. (eds.), Mitochondrial Dysfunction in Neurodegenerative Disorders, DOI 10.1007/978-0-85729-701-3_2, © Springer-Verlag London Limited 2012 Abstract Mitochondria are critically responsible for the generation of energy in the form of ATP through the electron transport chain (ETC). The central nervous system (CNS) performs highly energy-intensive tasks and is therefore particularly...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2013
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2012.10.006